Post traumatic tetanus and role of magnesium sulphate.

نویسندگان

  • Rana Imran Sikendar
  • Bader us Samad
  • Safdar Ali
  • Mohammad Iqbal Memon
چکیده

BACKGROUND Tetanus is a life threatening disease. Reported mortality for tetanus is 15-39%. Conventional treatment includes heavy sedation and artificial ventilation. Complications resulting from long term heavy sedation and artificial ventilation contribute to 60% of the total mortality caused by tetanus. In this study magnesium sulphate was used to reduce the need for sedation and artificial ventilation. Objectives of this prospective study were to determine the role of magnesium sulphate in post traumatic tetanus. METHODS The study was carried out in surgical Intensive Care at Pakistan Institute of Medical Sciences (PIMS), Islamabad from Jan 2004 to Dec 2007. Forty-four patients presented during this period and 33 patients were included in the study. All patients had tracheostomy done within 48 hours. Every patient was started Magnesium Sulphate therapy for control of spasms after sending baseline investigations. Patients were given ventilatory support when needed. All data was entered in well structured proforma. SPSS-10 was used to analyse data. RESULTS Thirty-three patients were included in the study and all patients were given magnesium sulphate. Out of these, 45.5% cases were grade 4 tetanus, 73.6% and 63.3% cases did not require artificial ventilation and additional sedation respectively, 51.1% patients remained free of complications of tetanus. Overall mortality was 30.3%. CONCLUSIONS Use of Magnesium Sulphate is safe and reduces the need for sedation and artificial ventilation in high grade tetanus thus contributing to survival benefit in adult post-traumatic tetanus cases.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

A Case of Tetanus Treated with Serum and Magnesium Sulphate

He was at once put in a dark room, the ulcer was cauterized with carbolic acid and regularly treated with antiseptic dressings and the following treatment was adopted:? 23?*c? March.?Morning?6,000 international units of tetanus antitoxic serum was given intramuscularly12 a.m.?-Two c.cm. of 25 per cent magnesium sulphate solution intravenously and at 6 p.m.?0,000 international units of tetanus a...

متن کامل

The Effects of Intraspinal Injection of Magnesium Salts upon Tetanus

Intraspinal injections of magnesium sulphate, in doses which do not affect the respiratory centre or other vital function, are capable of abolishing completely all clonic convulsions and tonic contractions in cases of human tetanus, and experimental tetanus in monkeys. The relaxing effects of the injections may last twenty-four hours or longer. In experimental tetanus in monkeys early intraspin...

متن کامل

Neonatal Tetanus in Vietnam: Comprehensive Intensive Care Support Improves Mortality

We report a 66% reduction in neonatal tetanus mortality after introducing a new management bundle integrating antibiotic therapy, muscle relaxation and invasive monitoring. The latter allowed rapid detection of autonomic instability which was treated with magnesium sulphate. This is the first report of its use in neonatal tetanus.

متن کامل

Remifentanil in the management of severe tetanus.

A 61-yr-old woman presented with severe tetanus. Her intensive care management was complicated by severe generalized tetanic spasms despite the use of propofol, midazolam, alfentanil, magnesium sulphate, and atracurium. We describe the management of this problem with a variable dose remifentanil infusion.

متن کامل

Iatrogenic hypocalcaemia following magnesium sulphate therapy in a patient with tetanus.

Ceylon Medical Journal Magnesium sulphate is increasingly being used in clinical practice, especially in the management of eclampsia, tetanus and severe bronchial asthma. Magnesium is known to influence the body’s calcium homeostasis. Hypomagnesaemia leads to hypocalcaemia by inducing resistance to parathormone (PTH) in bone and kidneys and by decreasing PTH release. Interestingly, hypermagnesa...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Journal of Ayub Medical College, Abbottabad : JAMC

دوره 21 2  شماره 

صفحات  -

تاریخ انتشار 2009